What is Pulmonary Fibrosis

Pulmonary fibrosis is a chronic lung condition that makes it difficult to breathe normally. Pulmonary fibrosis is associated with many lung diseases including:
- Idiopathic pulmonary fibrosis (IPF)
- Other interstitial lung diseases (ILDs) or pneumonias
- Chronic hypersensitivity pneumonitis (a special kind of an allergic reaction that occurs primarily in the lungs)
- Occupational lung disease (such as exposure to asbestos or silica)
Read More...
Pulmonary fibrosis is a chronic lung condition that makes it difficult to breathe normally. Pulmonary fibrosis is associated with many lung diseases including:
- Idiopathic pulmonary fibrosis (IPF)
- Other interstitial lung diseases (ILDs) or pneumonias
- Chronic hypersensitivity pneumonitis (a special kind of an allergic reaction that occurs primarily in the lungs)
- Occupational lung disease (such as exposure to asbestos or silica)
Read More...


What is INOpulse Therapy?



Includes a nasal cannula and drug cartridge for daily use

Weighs about 2.5 pounds

Works with most existing oxygen systems to deliver the iNO without changing your normal oxygen therapy regimen

Automatically adjusts to the patient’s breathing to ensure delivery of a constant, specific dose of iNO over time
INOpulse is a combination therapy designed to deliver inhaled nitric oxide (iNO) directly to a patient’s lungs via a delivery device and a proprietary nasal cannula. iNO is able to target the well-ventilated parts of the lungs (those areas less affected by fibrosis) and may help open blood vessels to reduce the pressure in the lungs and allow more oxygen to be delivered to the body.
The REBUILD Study
REBUILD is a phase 3 research study designed to investigate whether iNO delivered via INOpulse improves exercise tolerance (ability to do activities) in patients with pulmonary fibrosis. Exercise tolerance is measured using a wrist-worn activity monitor.
You may be eligible to take part in this study if you are:
Additional eligibility requirements are detailed at:
https://clinicaltrials.gov/ct2/show/NCT03267108
What the REBUILD Study Looks Like
People who participate in the REBUILD Study may already be taking FDA approved medications to treat pulmonary fibrosis such as Ofev® (nintedanib) or Esbriet® (pirfenidone). REBUILD participants will receive the INOpulse device with cartridges containing either the active drug (iNO) or a placebo (inactive drug), which can be used in addition to most prescribed treatments, including treatments for pulmonary fibrosis.
If you or a loved one has pulmonary fibrosis and may be interested in taking part in the REBUILD Study, please look for a study center in your area or review the REBUILD FAQs. You can also learn more about this research study at https://clinicaltrials.gov/ct2/show/NCT03267108.

Find a Study Site Near You
Find a REBUILD Study Site
Near You to Learn More

Find a study site near you by talking with your healthcare provider and entering your location below.
Search by US or Canada ZIP/Postal Code
Enter a valid 5-Digit US or 6-Character Canada Postal Code
1. Vanderbilt University Medical Center
719 Thompson Lane, Suite 20300, Nashville, TN 37204
F: 615-322-3755
Principal Investigator
Rosemarie Dudenhofer
P: 615-343-7068
E: rosemarie.dudenhofer@vumc.org
Study Coordinator
James Del Greco, MSN, RN
P: 615-322-0476
2. University of Michigan
1500 East Medical Center Drive, 3916 Taubman Center, SPC 5360, Ann Arbor, MI 48109
F: 734-936-5048
Principal Investigator
Elizabeth Belloli
P: 734-647-6477
P: 519-667-6723
Primary Study Coordinator
Courtney Graft, BA, CCRP
P: 734-232-2214
Backup Study Coordinator
Linda Briggs
P: 734-232-5844
3. Inova Heart and Vascular Institute, Advanced Lung Disease Clinic
3300 Gallows Road, Falls Church, VA 22042
F: 703-776-7691
Principal Investigator
Christopher King
P: 703-776-6147
Primary Study Coordinator
Priscila Dauphin
P: 703-776-7128
Backup Study Coordinator
Rebecca Hays
P: 703-776-5444
Backup Study Coordinator
Megan Harbour
P: 703-776-3230
4. Medical University of South Carolina
96 Jonathan Lucas Street, CSB 816, MSC 630, Charleston, SC 29425
F: 843-792-0401
Principal Investigator
Rahul Argula
P: 843-792-2072
Primary Study Coordinator
Lauren McGarry
P: (843) 792-1221
5. Emory University
1365 Clifton Road, A3226, Atlanta, GA 30322
F: 404-712-8636
Principal Investigator
Srihari Veeraraghavan
P: 404-712-7458
Primary Study Coordinator
Mitzi Near
P: 404-712-9603
6. Piedmont Healthcare Pulmonary and Critical Care Research
3820 Medical Park Drive, Suite 1100, Austell, GA 30106
F: 770-944-2154
Principal Investigator
Amy Case
P: 770-745-1404, ext2
Primary Study Coordinator
Olayinka Elemide
P: (404) 670-5361
E: Olayinka.elemide@piedmont.org
Backup Study Coordinator
Halle Sovich
P: (470) 561-1556
Backup Study Coordinator
Ugonna Nwosu
P: (404) 291-9062
7. The Lung Research Center, LLC
222 S. Woods Mill Road, Suite 300 North, Chesterfield, MO 63017
F: 314-576-9854
Principal Investigator
Neil Ettinger
P: 314-682-3653
E: neil.ettinger@stlukes-stl.com
Primary Study Coordinator
Anna Shipp
P: 314-682-3652
8. University of California, Davis Medical Center
4150 V Street, Suite 3400, Sacramento, CA 95817
F: 916-734-0861
Principal Investigator
Dr. Namita Sood
P: 916-734-3576
Primary Study Coordinator
Cynthia Perry-Baker
P: 916-734-1554
Backup Study Coordinator
Amanpreet Kaur
9. The University of Texas Southwestern Medical Center
5939 Harry Hines Boulevard, POB II Ste. HQ1.200, Dallas, TX 75390
F: 210-885-8936
Principal Investigator
Edward Mims
P: 214-645-6493
E: edward.mims@utsouthwestern.edu
Primary Study Coordinator
Mary Martin
P: 214-645-6219
E: Mary.Martin@utsouthwestern.edu
Backup Study Coordinator
Alexia Albarracin
P: 214-645-6488
10. University of Utah Health Sciences, Pulmonary Clinical Research
419 Wakara Way, Suite 207, Salt Lake City, UT 84108
F: 801-585-5194
Principal Investigator
Mary Beth Scholand
P: 801-581-5811
E: mary.beth.scholand@hsc.utah.edu
Primary Study Coordinator
Andriea Merie Smith
P: 801-581-5811
Backup Study Coordinator
Chloe Kirkpatrick
P: 801-694-3947
11. Pulmonary Associates of Richmond
6600 West Broad Street, Suite 300, Richmond, VA 23230
F: 804-288-5947
Principal Investigator
Shilpa Johri
P: 804-288-5945
Primary Study Coordinator
Betsy Daniel
P: 804-396-4421
Backup Study Coordinator
Laura Lincoln
P: 804-288-5945
12. University of Miami
1321 NW 14th Street, West Bldg #606 , Miami, FL 33125
F: 305-243-3738
Principal Investigator
Roger Alvarez
P: 305-243-2568
Primary Study Coordinator
Karla Leon Escalona
P: 305-243-2568
13. Norton Pulmonary Specialists, fka Kentuckiana Pulmonary Associates
100 West Market Street, Suite 2, Louisville, KY 40202
F: 502-583-8001
Principal Investigator
John McConnell
P: 502-587-8000
Primary Study Coordinator
Kimberly (Kim) Hobbs Robinson, APRN, FNP-BC
P: 502-587-8000
14. Temple University, Department of Thoracic Surgery and Medicine
3440 N. Broad Street, Kresge Bldg, Suite 700, Philadelphia, PA 19140
F: 215-707-8043
Principal Investigator
Jeffrey Stewart
P: 215-707-4260
E: Jeffrey.Stewart@tuhs.temple.edu
Primary Study Coordinator
Delores (Dee) Fehrle, BSN, MHA
P: 215-707-4260
15. University of Colorado Hospital, Anschutz Medical Campus
12631 E. 17th Avenue, Rm. 8206, C272, Aurora, CO 80045
F: 303-724-7835
Principal Investigator
Todd Bull
P: 303-724-7466
Primary Study Coordinator
Blake Butler
P: 303-724-7466
E: blake.butler@cuanschutz.edu
Backup Study Coordinator
F. Danielle Peacock
P: 303-724-7466
16. Loyola University, Medical Center, Health Science Campus
2160 S. First Avenue, Research and Education Building 115, Suite 253, Maywood, IL 60153
F: 708-216-2059
Principal Investigator
Daniel Dilling
P: 708-216-5744
Primary Study Coordinator
Josephina Corral
P: 708-216-5744
Backup Study Coordinator
Aerial Williams
P: 708-537-7122
17. Arizona Pulmonary Specialists, Ltd.
3330 North 2nd Street, Suite 300, Phoenix, AZ 85012
F: 602-443-0188
Principal Investigator
Jeremy Feldman
P: 602-271-0832
Primary Study Coordinator
Stephen Fuller
P: 602-271-0832
E: stephen-research@hotmail.com
Backup Study Coordinator
Lorraine Stroud, LPN, CCRC (Director Clinical Research)
18. University of Cincinnati, College of Medicine/Pulmonary, Medical Science Building
231 Albert Sabin Way, Room 6053, Cincinnati, OH 45267-0564
F: 513-558-4858
Principal Investigator
Nishant Gupta
P: 513-558-2148
Primary Study Coordinator
Emillie Hoh
Backup Study Coordinator
Jessica Anderson
Backup Study Coordinator
Carrie Keininger
19. Thomas Jefferson University, Korman Respiratory Institute
211 S. 9th Street, Suite 401, Philadelphia, PA 19107
Principal Investigator
Gautam George
P: 215-955-9181
E: gautam.george@jefferson.edu
Primary Study Coordinator
Disha Singh
P: 215-955-3838
Backup Study Coordinator
Djamila Mallem
P: 215-955-9181
E: djamila.mallem@jefferson.edu
Backup Study Coordinator
Michelle Hampton
P: 215-955-9181
20. The University of North Carolina at Chapel Hill
300 Meadowmont Village Circle, Suite 204, Chapel Hill, NC 27517
Principal Investigator
Mazen Al-Qadi
P: 401-834-0709
E: Mazen.Al-qadi@unchealth.unc.edu
Primary Study Coordinator
Blondell (Paula) Glover
P: 984-974-2966 (O)
P: 678-266-0401 (M)
21. Avanza Medical Research Center
4700 Bayou Boulevard, Suite 4, Pensacola, FL 32503
Principal Investigator
Peter Bercz
P: 850-972-9322
Primary Study Coordinator
Maryam Mirzaie
P: 850-898-2182
E: m.mirzaie@avanzaresearch.com
Backup Study Coordinator
Brittany Hardy
Backup Study Coordinator
Luz Harris
E: l.harris@avanzaresearch.com
Backup Study Coordinator
Garwin Ho
Backup Study Coordinator
Molham Lucy
22. NYU Langone Medical Center
462 First Avenue, 4th Floor, New York, NY 10016
Principal Investigator
Roxana Sulica
P: 646-880-7584
E: Roxana.Sulica@nyulangone.org
Primary Study Coordinator
Anabela Barroso
P: 212-263-9189
23. University of South Florida (Tampa General Hospital)
5 Tampa General Circle, HMT 500, Tampa, FL 33612
F: 813-844-5816
Principal Investigator
Debabrata Bandyopadhyay
P: 216-496-0561
Primary Study Coordinator
Victoria Parray
P: 813-844-8624
Backup Study Coordinator
LaShae Rolle
24. Creighton University
7710 Mercy Road, Suite 228, Omaha, NE 68124
F: 402-280-4145
Principal Investigator
Lee Morrow
P: 402-280-4125
Primary Study Coordinator
Theresa Ramelb
P: 402-280-4142
E: TheresaRamelb@creighton.edu
Backup Study Coordinator
Rob Ericksen
25. Univ of TX Health Science Center at Houston
6400 Fannin Street, Suite 2350, Houston, TX 77030
F: 713-486-6730
Principal Investigator
Soma Jyothula
P: 813-748-4080
E: soma.s.jyothula@uth.tmc.edu
Primary Study Coordinator
Christa Miles
P: 713-500-7585
Backup Study Coordinator
Chandni Patel, BS CCRP (Program Manager)
P: 713-486-6702
26. Amicis Research
9241 Reseda Boulevard, Suite B, Northridge, CA 91324
F: 213-394-3190
Principal Investigator
Sasan Sani
P: 818-924-4708
Primary Study Coordinator
Harvey Rosales
P: 818-644-2242
E: harvey.rosales@amicisresearch.com
Backup Study Coordinator
Tyrone Rosales (site manager)
P: 818-924-4708
27. Baylor University Medical Center
3410 Worth Street, Suite 560, Dallas, TX 75246
F: 214-820-1474
Principal Investigator
Yolanda Mageto
P: 214-865-3624
E: yolanda.mageto@bswhealth.org
Primary Study Coordinator
Eva Patel
P: 214-820-5829
Backup Study Coordinator
Shelby Shull
Backup Study Coordinator
Camille Harry
28. St. Francis Sleep Allergy and Lung Institute
804 N. Belcher Road, Clearwater, FL 33765
F: 727-210-4609
Principal Investigator
Francis Averill
P: 727-210-4606
E: faverillresearch@stfrancismed.com
Primary Study Coordinator
Amber Dunn
P: 727-210-4606
P: 727-403-6371 (mobile)
Backup Study Coordinator
Catherine Preston (mgr)
P: 727-210-4606
29. University Hospitals
11100 Euclid Avenue, Cleveland, OH 44106
Principal Investigator
Robert Schilz
P: 216-368-8601
E: robert.schilz@uhhospitals.org
Primary Study Coordinator
Xiuhua Yuan
P: 216-844-2371
E: Xiuhua.Yuan@Uhhospitals.org
Backup Study Coordinator
Mandy Rivera, RRT
P: 216-844-4908
30. Stanford University
300 N Pasteur Drive, Rm. H3143, Stanford, CA 94305
F: 650-724-6096
Principal Investigator
Joshua Mooney
P: 650-725-7061
Primary Study Coordinator
Karen Morris
Backup Study Coordinator
Susan Jacobs, RN, MS, FAAN
P: 650-725-8083
31. Atlantic Respiratory Institute
1 Springfield Avenue, Suite 2B, Summit, NJ 07901
F: 908-934-0556
Principal Investigator
Matthew Epstein
P: 862-432-2279
E: matthew.epstein@atlantichealth.org
Primary Study Coordinator
Julianna Colecchia
P: 908-934-0440
E: Juliana.colecchia@atlantichealth.org
Backup Study Coordinator
Marissa Rienton-Lim
P: 862-345-4842
E: Marissa.Rienton-Lim@atlantichealth.org
Backup Study Coordinator
Marta Marut
P: 862-777-3787
32. Advanced Pulmonary Research Institute
13005 Southern Boulevard, Loxahatchee, FL 33470
F: 561-792-0361
Principal Investigator
Neal Warshoff
P: 561-795-1022
Primary Study Coordinator
Liudmila (Mila) Moreiras, MSN, APRN
P: 561-795-1022
P: 561-846-0084
33. Paloma Medical Group
30230 Rancho Viejo Road, Suite 200, San Juan Capistrano, CA 92675
F: 949-443-4033
Principal Investigator
Michael Rovzar
P: 949-443-4303
Primary Study Coordinator
Michael Gloriani
P: 949-637-8088
34. University of Alabama
1900 University Blvd., THT 513, Birmingham, AL 35294
F: 205-934-6229
Principal Investigator
Tracy Luckhardt
P: 734-678-6679
Primary Study Coordinator
Brittany Harrison, RN
P: 205-934-4440
Backup Study Coordinator
Melessia Wells
35. Stony Brook University Hospital, Health Sciences Center
101 Nicolls Road, T-17-040, Stony Brook, NY 11794
F: 631-444-7502
Principal Investigator
Paul Strachan
P: 631-444-9924
E: Paul.Strachan@stonybrook.edu
Primary Study Coordinator
Jacqueline (Jackie) Skarre, MS, RN, ANP-C, CRC
P: 631-444-9033
36. Southern Illinois University #1
751 N. Rutledge Street, Suite 2100, Springfield, IL 62702
Principal Investigator
Rajagopal Sreedhar
P: 217-545-8000
Primary Study Coordinator
Rebecca Coughlin
P: 217-545-7321
Backup Study Coordinator
Lori Miedwig, MA, CCRP
P: 217-545-4402
Backup Study Coordinator
Katharine Blancett
P: 217-545-7799
37. Southern Illinois University #2
201 E Madison Street, Rm 251, Springfield, IL 62702
Principal Investigator
Rajagopal Sreedhar
P: 217-545-8000
Primary Study Coordinator
Rebecca Coughlin
P: 217-545-7321
Backup Study Coordinator
Lori Miedwig, MA, CCRP
P: 217-545-4402
Backup Study Coordinator
Katharine Blancett
P: 217-545-7799
38. Northside Hospital
1000 Johnson Ferry Road NE, Building 993D, Suite 300, Atlanta, GA 30342
F: 404-851-6847
Principal Investigator
Paul Boyce
P: 404-257-0006
E: Paul.BoyceM.D@northside.com
Primary Study Coordinator
Nancy Bryant
P: 404-236-8351
Backup Study Coordinator
Tamara Wakhisi
P: 404-236-8322
39. NorthShore University
2650 Ridge Avenue, Room 5319, Evanston, IL 60201
F: 847-733-5109
Principal Investigator
Shashi Bellam
P: 847-570-2714
Primary Study Coordinator
Naomi Ben-Israel Olive
P: 414-779-0654
E: NBenIsraelOlive@northshore.org
Backup Study Coordinator
Adam Vanderloo (Research Manager)
P: (847) 570-4208 (Evanston Hospital)
P: (224) 364-7107 (Research Institute)
40. AnMed Health
800 North Fant Street, Anderson, SC 29621
F: 864-716-1271
Principal Investigator
Abhijit Raval
P: 864-512-8551
Primary Study Coordinator
Charlesa Davis
P: 864-512-1291
E: charlesa.davis2@anmedhealth.org
Backup Study Coordinator
Melissa Frankum
P: 864-512-1291
E: melissa.frankum@anmedhealth.org
Backup Study Coordinator
Kelly Jarvis
P: 864-512-1291
41. Ascension St. Vincent Hospital
8333 Naab Road, Suite 400, Indianapolis, IN 46260
F: 317-338-9129
Principal Investigator
Ashwin Ravichandran
P: 317-338-6666
E: ashwin.ravichandran@ascension.org
Primary Study Coordinator
Diane Slama
P: 317-338-6717
Backup Study Coordinator
Anne Renick
P: 317-338-6152
42. Weill Cornell
425 E 61st Street, 4th Floor, Suite 402, New York, NY 10065
F: 646-962-0286
Principal Investigator
Robert Kaner
P: 646-962-2333
Primary Study Coordinator
Alicia Morris
P: 646-962-2741
Backup Study Coordinator
Lianne De La Cruz
43. Metroplex Pulmonary and Sleep
4833 Medical Center Drive, Unit 6B, McKinney, TX 75069
F: 972-838-1896
Principal Investigator
Shakrukh Kureishy
P: 972-838-1892
E: shahrukh_kureishy@yahoo.com
Primary Study Coordinator
Ambreen Ahmed, MBBS
P: 972-838-1892
Backup Study Coordinator
Rupa Krishna
Backup Study Coordinator
Rebecca Cady
Backup Study Coordinator
Lubna Mateen
Backup Study Coordinator
Nurunnisa Banu
E: nur.banu.mpsleepcenter@gmail.com
Backup Study Coordinator
Samina Wahid
Backup Study Coordinator
Shilpa Patel
44. Georgetown University
3800 Reservoir Road Northwest, Washington , DC 20007
Principal Investigator
Tunay Kuru
P: 202-444-8830
Primary Study Coordinator
Amen Hamed
P: 202-444-0895
E: Amen.Hamed@gunet.georgetown.edu
Backup Study Coordinator
Camisha Toby-Pierre
45. National Jewish
1400 Jackson Street, Denver, CO 80206
F: 303-398-1780
Principal Investigator
M. Patricia George
P: 303-398-1096
Primary Study Coordinator
Jennifer Underwood
P: 303-398-1518
Backup Study Coordinator
Kristina Eliopoulos
46. Johns Hopkins Hospital
1830 E. Monument Street Bldg., 5th floor, Baltimore, MD 21205
F: 410-614-1652
Principal Investigator
Maureen Horton
P: 410-614-1652
Primary Study Coordinator
Sarah Collins
P: 410-550-2062
47. University of Louisville
501 E. Broadway, Suite 210, Louisville, KY 40202
F: 502-852-1721
Principal Investigator
Alex Ng
P: 502-852-5841
Primary Study Coordinator
Joan Hamlyn
P: 502-852-8739
48. Oregon Clinic
1111 NE 99th Avenue, Suite 200, Portland, OR 97220
F: 503-963-3196
Principal Investigator
David Hotchkin
P: 503-963-3030
Primary Study Coordinator
Meg Day, CCRP
P: 503-963-3182
49. Ohio State
452 West 10th Avenue, Columbus, OH 43210
F: 614-293-5904
Principal Investigator
Elie Homsy
P: 614-293-4299
Primary Study Coordinator
Alec Vest
P: 614-685-4624
Backup Study Coordinator
Melissa Kleis
P: 614-366-7843
Backup Study Coordinator
Jennifer Smith
50. Northwestern
633 N St Clair Street, Suite 18-041, Chicago, IL 60611
Principal Investigator
Rade Tomic
P: 312-664-3278
Primary Study Coordinator
Phillip Cooper
P: 312-503-0406
Backup Study Coordinator
Aaron Gundersheimer
51. University of Arizona/Banner Health
755 E. McDowell Road, 3rd Floor, Phoenix , AZ 85006
F: 602-839-7663
Primary Investigator
Ramachandra Sista
P: 602-521-3189
E: ramachandra.sista@bannerhealth.com
Primary Study Coordinator
Susan Sheerin-Fadden
P: 623-466-2685
Backup Study Coordinator
Elena Young
P: 602-255-7553
52. PulmonIx, LLC / LeBauer Cone Health
3511 West Market St, Suite 240, Greensboro, NC 27403
F: 336-522-8875
Primary Investigator
Murali Ramaswamy
P: O: 336.522.8870
P: C: 336.908.2900
E: murali.ramaswamy@pulmonix.com
Primary Study Coordinator
Shaina Gold
P: 336-522-8870
Backup Study Coordinator
Jennifer Castillo
P: 336-552-8871
53. University of Pennsylvania
3400 Spruce Street, Philadelphia, PA 19104
Primary Investigator
Mary Elizabeth (Maryl) Kreider
P: 215-614-1939
E: MaryElizabeth.Kreider@pennmedicine.upenn.edu
Primary Study Coordinator
Sarah Alam
P: P: 215-662-6280
P: M: 609-668-7771
E: sarah.alam@pennmedicine.upenn.edu
Backup Study Coordinator
Melissa Molter
54. Mount Sinai Hospital
One Gustave L Levy Place, New York, NY 10029
F: 212-241-3684
Primary Investigator
Maria Trivieri
P: 212-241-3477
E: mariagiovanna.trivieri@mountsinai.org
Primary Study Coordinator
Elizabeth Tinuoye (Program Manager/Clinical Researcher)
P: 646-670-8569
55. University of British Columbia
2775 Laurel Street, 7th Floor, Vancouver, BC V5Z 1M9
F: 604-875-4695
Principal Investigator
Nasreen Khalil
P: 604-875-4122
Primary Study Coordinator
Marion Santos
P: 604-875-5091
Backup Study Coordinator
Shelley Abercromby
56. London Health Sciences Centre
800 Commissioners Road East, Room E6-201, London, ON N6A 5W9
F: 519-685-8406
Principal Investigator
Sanjay Mehta
P: 519-667-6723
Primary Study Coordinator
Leila Macbean
P: 519-685-8500